J & J’s COVID booster boosts antibodies nine-fold: updates
Johnson & Johnson said on Wednesday that studies showed that a booster dose of its vaccine offered a nine-fold increase in antibodies compared to the vaccine alone.
The studies, published by Johnson & Johnson, come as the United States prepares next month to offer a third dose to those who have received the Pfizer and Moderna vaccines.
Johnson & Johnson’s announcement said studies showed that a booster dose of its vaccine showed “a rapid and robust increase in spike binding antibodies, nine times greater than 28 days after primary dose vaccination. unique”. The company said it was working with federal officials, including the Food and Drug Administration and the Centers for Disease Control and Prevention, on next steps to strengthen the effects of the vaccine and prepare for a possible booster.
The announcement came as CDC studies show vaccines are less effective against delta and an increased need for such booster shots, although vaccines are still essential to prevent hospitalizations.
A CDC study released Tuesday shows vaccine protection may wane over time as the delta variant increases across the country. Once delta became the dominant strain in the United States, the vaccine’s effectiveness against the infection declined from 91% to 66%.
A second CDC study found that a quarter of COVID-19 infections between May and July in Los Angeles were breakthrough cases, but hospitalizations were significantly lower for those who had been vaccinated. Unvaccinated people were more than 29 times more likely to be hospitalized than vaccinated people, and about five times more likely to be infected.
Also in the news:
►Tennessee topped 1 million COVID-19 cases on Tuesday amid an increase in hospitalizations and the rapid spread of the virus among unvaccinated and school-aged children. It’s the 12th state to cross the threshold, according to data from Johns Hopkins University.
►Georgia on Tuesday called in more than 100 National Guard soldiers to help hospitals overwhelmed with COVID-19 cases. Kentucky also called in troops on Monday due to power surges.
►New York Governor Kathy Hochul said requiring vaccinations or weekly tests for teachers and staff in Kindergarten to Grade 12 and imposing masks inside schools will be among his first actions after being sworn in as governor on Tuesday.
►More than 1,000 attendees at Latitude Festival, a British music festival, tested positive for COVID-19, the BBC reported.
►China has warned residents of at least 12 cities that they could be punished for refusing a COVID-19 vaccine if they are later linked to an outbreak, the New York Times reported.
►Health officials warn people not to use a medicine called ivermectin, an animal dewormer, to treat or prevent COVID-19 after multiple hospitalizations.
The numbers of the day: United States has recorded nearly 38 million confirmed cases of COVID-19 and more than 630,000 deaths, according to Johns Hopkins University The data. Global totals: Over 213 million cases and 4.45 million deaths. More than 171 million Americans – 51.6% of the population – have been fully immunized, According to the CDC.
What we read: COVID-19 vaccines for young children: when are they coming? And what is the status of clinical trials? Here’s what you need to know.
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For most of this year, the drugs President Donald Trump credited for his rapid recovery from COVID-19 have gone unused on government shelves. But now the demand is skyrocketing.
Regeneron, the Tarrytown, New York, company that makes a monoclonal antibody, shipped more than 150,000 doses of REGN-COV2 nationwide this week. By mid-July, he sent less than 25,000 doses per week.
Demand for sotrovimab, another monoclonal antibody cleared for use against COVID-19, has increased by almost 300% over the past month.
The extra boost, said Dr Howard Huang, who led the Houston Methodist Hospital monoclonal antibody effort, likely comes from increased COVID-19 cases, increased awareness from the public to drugs and the successful experiences of physicians with them earlier in the pandemic.
– Karen Weintraub
Shortly before noon on Friday, Jacquelyn Graham-Townes leaned over a white coffin containing another person who came into her care because of the coronavirus.
She echoed what doctors and nurses at local hospitals have been saying for weeks: What’s happening in Jacksonville now is worse than anything the city has seen in 2020.
Last year, the morgue took care of funeral arrangements for about five deaths from COVID-19.
“I did four in one day,” she said. “It’s like the floodgates have opened.”
Florida is inundated with COVID-19 infections and Duval County is struggling to keep its head above water. The 1,486 Floridians reported dead the week ending Friday are nearly 15% higher than the previous worst week in January. Hospitalizations as of Saturday were nearly 70% higher than last winter’s peak.
Everything was on display in Jacksonville. More than 70 people have died this month alone from COVID at UF Health Jacksonville trauma center. People lined up to receive the REGEN-VOC antibody cocktail from the company Regeneron in an effort to prevent serious illness. In schools, parents, teachers and students are worried about the potential for the virus to spread. Read more here.
– Mark Woods, Nada Hassanein, Emily Bloch and David Bauerlein
Last year’s flu season was the mildest on record, but health experts have renewed warnings that a “twindemia” – in which flu and COVID-19 cases are increasing and simultaneously overwhelming hospitals – may be possible this year, and they are urging Americans to get the flu shot.
Health experts say this year may look like a more typical flu season, as students resume face-to-face learning and states loosen mask and social distancing mandates amid a return to the media. social gatherings. This is all the more concerning as cases of COVID-19 driven by the delta variant are increasing across the country.
“We were worried about ‘twindemia’ last year and we are facing the same threat this year,” said Dr Daniel Solomon, physician in the infectious disease division of Brigham and Women’s Hospital. “COVID-19 is likely to continue, and we face the threat of double respiratory viruses that could strain our healthcare system. “
– Adrianna Rodriguez
The full approval by the Food and Drug Administration of the Pfizer-BioNTech COVID-19 vaccine has launched a flood of vaccination warrants across the United States that will push millions of Americans to get vaccinated or face serious consequences.
The range of people covered by vaccine requirements following Monday’s action now includes the U.S. military, New York public school teachers and staff, all teachers and state employees from New Jersey, students from several university systems, corporate employees and pharmacists from CVS Health, and 30,000 unionized workers at Disney World.
Defense Secretary Lloyd Austin said in a memo on Wednesday that he was ordering department heads “to impose ambitious deadlines for the implementation” of vaccine requirements.
This adds to the millions of Americans for whom delaying COVID-19 vaccination could mean anything from having to get tested for the virus every week to losing their jobs or being banned from going to school. ‘school.
The White House received a new classified intelligence report on the origins of the coronavirus on Tuesday, but it did not come to a solid conclusion as to whether the the virus originated in animals before being transferred to humans or was released from a laboratory, according to reports.
Biden had asked the intelligence community in May to step up efforts to investigate the origins of COVID-19 after officials could not agree on a conclusion. According to The Washington Post, intelligence officials will seek to release parts of the report.
The Wall Street Journal reported that U.S. officials said part of the reason for the lack of a conclusion was a lack of information about China.
“It was a deep dive, but you can’t go as far as the situation allows,” a US official told The Wall Street Journal. “If China doesn’t provide access to certain datasets, you’ll never really know. “
The World Health Organization and China concluded in March that it was “extremely unlikely” that the virus escaped from a laboratory, a theory that has emerged from a series of sources with circumstantial evidence, including including repeated claims by former President Donald Trump and his allies, without citing specific evidence.
A handful of schools are charge thousands of dollars to unvaccinated students in COVID-19 testing fees to stay on campus this fall during the pandemic.
And some schools are imposing additional penalties: Quinnipiac University in Hamden, Connecticut, announced that in addition to fining unvaccinated students, it would cut off their campus’s Wi-Fi access.
Now schools are starting to de-enroll unvaccinated students.
Last week, the University of Virginia deregistered 49 students who did not comply with the school’s vaccination mandate. Xavier University of Louisiana, a private Catholic HBCU in New Orleans, confirmed to USA TODAY that it had also started de-enrolling unvaccinated students on Monday, the first day of class.
Rowan University, a public school in Glassboro, New Jersey, announced Monday that with full approval of the Pfizer vaccine by the FDA, students have until September 7 to be vaccinated. After this day, students who cannot prove vaccination or who have a valid declination form risk having their “accounts suspended, removed from residences (if applicable) and possibly removed from the University”. Read more here.
– Lindsay Schnell
Contribution: The Associated Press